Furthermore, hesperidin was found to attenuate sarcopenia by regulating the AKT (protein kinase B)/mTOR (mammalian target of rapamycin)/FoxO3a (forkhead box O3a) signaling pathway, leading to an increased expression of insulin-like growth factor (IGF-1), which is essential for muscle growth and maintenance (48). This evidence concerns the gene MTOR and sarcopenia.