Together, these findings establish GNB2 as a direct RNA-binding partner of Snhg5 in colorectal cancer cells and indicate that Snhg5 enhances GNB2 expression at least in part by stabilizing both Gnb2 mRNA and GNB2 protein, supporting the presence of a functional Snhg5–GNB2 RNA–protein axis potentially involved in metastatic signaling regulation. The gene discussed is SNHG5; the disease is colorectal cancer.