AXIN1 and hepatocellular carcinoma: As mutations in core Wnt/β-catenin pathway components are late events in HCC development and Axin1-deficient mice show delayed tumorigenesis (>1 year),10,14,59 we anticipate that additional mutations are necessary for HCC progression and that differences in mutational background may impact on the degree of YAP/TAZ activation in these cancer cells.