EIF4EBP1 and acute myeloid leukemia: In accordance with the results of bioinformatics analyses, the expression levels of phosphorylated 4E-BP1, downstream of mTORC1,16 among lineage–CD34–Runx2+ cells of the BM were significantly increased in patients with both MDS and AML compared to those in control participants (Figures 1H and 1I).