In accordance with the results of bioinformatics analyses, the expression levels of phosphorylated 4E-BP1, downstream of mTORC1,16 among lineage–CD34–Runx2+ cells of the BM were significantly increased in patients with both MDS and AML compared to those in control participants (Figures 1H and 1I). Here, RUNX2 is linked to acute myeloid leukemia.