In accordance with the results of murine scRNA-seq datasets, bulk RNA sequencing (bulk RNA-seq) analysis revealed that the mTORC1 signaling was significantly enriched in healthy-subject-derived primary human osteoblasts co-cultured with human AML cells carrying the MLL-AF9 fusion oncogene compared to that in cultured osteoblasts alone (Figure 1F). The gene discussed is KMT2A; the disease is acute myeloid leukemia.