BGLAP and acute myeloid leukemia: We screened three different cohorts and identified secreted and adherent factors in (1) human osteoblasts co-cultured with AML cells, (2) mTORC1-activated mature osteoblasts (derived from Osteocalcin-Cre;Tsc1fl/fl mice), and (3) mTORC1high murine osteoblasts (Figures 4A–4C).