RPTOR and leukemia: Deletion of Raptor was associated with the inhibition of leukemia in a murine AML model through apoptosis of differentiated leukemia cells, whereas transplantation of Raptor-deficient AML cells demonstrated that mTORC1 is critical for the initiation of leukemia, suggesting that the loss of mTORC1 supports the ability for self-renewal of leukemia stem cells.27