COX-3, a COX-1 variant sensitive to paracetamol, has been studied with AD in (Interleukin (IL)-1β + Aβ42)-stimulated human neuronal cultures, as COX-2 is elevated in AD while COX-3 is enriched in mammalian CNS (Warner and Mitchell, 2002; Cui et al., 2004). Here, IL1B is linked to Alzheimer disease.