The platelet-to-C-reactive protein ratio (PCR), a composite biomarker simultaneously evaluating coagulation function and inflammatory status, has demonstrated superior predictive performance of prognoses compared to isolated platelet or C-reactive protein measurements in sepsis, chronic heart failure, and COVID-19 (12–14), offering new insights for surgical decision-making and prognosis prediction in NEC patients with PVG. The gene discussed is CRP; the disease is necrotizing enterocolitis.