CGAS and cancer: Among these, stimulation of the cGAS-STING pathway is particularly attractive for therapeutic purposes, as it ultimately triggers a strong immune response that enhances the body's ability to recognize and attack cancer cells.45 Specifically, the enzyme cyclic GMP–AMP synthase (cGAS) senses DNA leakage into the cytoplasm—a hallmark of cancer cells—and produces a signaling molecule called cGAMP.