Furthermore, tumor-associated macrophages that expressed PD-L1 suppress CD8+T cell responses, which lead to T cell dysfunction and ineffectiveness, further induced tumor immunosuppression [[32], [33], [34]].Despite the immunotherapy of immune checkpoint inhibition can potentiate anti-tumoral immune response in GBM [[35], [36], [37]], additional experiments are warranted to delve into the underlying mechanisms linking SERPINA3 and glioma-associated macrophage (GAM) infiltration., and perhaps a novel strategy targeting SERPINA3 and combination therapy will be developed for glioma treatment. The gene discussed is CD274; the disease is glioblastoma.