Given the detrimental role of 5-HT in IBD and the elevated levels of TAAR1-activating amines (Tryp, PEA, and Tyr) in both UC and DSS-colitis models, we evaluated the therapeutic potential of TAAR1 inhibition in chronic DSS-colitis (Fig. 2A). The gene discussed is TAAR1; the disease is irritable bowel syndrome.