CLIC4 and cardiomyopathy: In cardiomyopathy (CMP), 5′tiRNA-Gln-TTG-001 expression is significantly upregulated in acute myocarditis and positively correlates with the ratio of high-sensitivity cardiac troponin T to troponin T. This molecule activates the Chloride intracellular channel protein 4 (CLIC4, a membrane-associated ion channel protein regulating cellular inflammation and damage) gene by binding to its 3′ untranslated region, thereby exacerbating inflammatory damage to cardiomyocytes through increased CLIC4 expression [89].