METTL1 and acute myeloid leukemia: In acute myeloid leukemia (AML) patients, the Methyltransferase 1/WD repeat domain 4 (METTL1/WDR4) complex catalyzes m7G modification of tRNA, enhancing translation efficiency of specific mRNAs (e.g., HOXA9, MEIS1) to maintain AML cell proliferation and stemness.