Furthermore, elevating tRF-Ala-AGC-3-M8 levels to suppress Ephrin type-A receptor 7 (EphA7) expression effectively blocked ERK1/2-p70S6K signaling in BV-2 and HT22 cells, thereby mitigating neuroinflammation and neuronal damage in AD [86]. Here, EPHA7 is linked to Alzheimer disease.