In vitro and in vivo experiments indicate that tsRNA-GlyGCC promotes CRC resistance to 5-fluorouracil by targeting Spleen-associated tyrosine kinase-binding protein (SPIB) to regulate the JAK1/STAT6 signaling pathway [69]; while tRF3008A suppresses proliferation and migration of CRC in vivo and in vitro by inhibiting endogenous Forkhead box protein K1 (FOXK1, a positive regulator of the Wnt/β-catenin pathway) [70]. This evidence concerns the gene STAT6 and colorectal carcinoma.