In acute myeloid leukemia (AML) patients, the Methyltransferase 1/WD repeat domain 4 (METTL1/WDR4) complex catalyzes m7G modification of tRNA, enhancing translation efficiency of specific mRNAs (e.g., HOXA9, MEIS1) to maintain AML cell proliferation and stemness. This evidence concerns the gene HOXA9 and acute myeloid leukemia.