CCL21 and neoplasm: Chemokine gradients such as those established by C-C motif chemokine ligand 19 (CCL19; encoded by CCL19), C-C motif chemokine ligand 21 (CCL21; encoded by CCL21), and C-X-C motif chemokine ligand 13 (CXCL13; encoded by CXCL13) along with high endothelial venules within TLSs, promote T cell homing to the tumor, where antigen-presenting cells (dendritic cells and B cells) present tumor antigens to naïve T cells locally [31,32].