CRK and breast cancer: Factors such as Annexin A1 (ANXA1; encoded by ANXA1), adapter molecule Crk (Crk; encoded by CRK), Cyclin-dependent kinase 8 (CDK8; encoded by CDK8), Guanylate-binding protein 5 (GBP5; encoded by GBP5), and Tumor necrosis factor receptor 2 (TNFR2; encoded by TNFRSF1B), play a role in increasing PDL1 expression, thereby facilitating immune evasion in breast cancer.