The expression of immunosuppressive cytokines, including transforming growth factor beta 1 (TGF-β1; encoded by TGFB1), and interleukin-10 (IL-10; encoded by IL10), together with immunoregulatory enzyme such as indoleamine 2,3-dioxygenase (IDO), as well as immune checkpoint molecules like programmed death-ligand 1 (PD-L1; encoded by CD274), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4, encoded by CTLA4), and lymphocyte activating-3 (LAG-3; encoded by LAG3), additionally hampers the body’s ability to create an efficient immune response against cancer [11–13]. The gene discussed is CD274; the disease is cancer.