LPL and cancer: Viewed together, these 5 cases demonstrate a diverse group of cancer types and LPL-cirAE presentations, including symptoms ranging from asymptomatic to intensely pruritic and with or without pain; variable morphologies; a wide variety of involved regions, with 2 of 5 involving mucosa; and unpredictable time to onset, ranging from within a week of therapy initiation to 8 months after discontinuing.