In diabetic cardiomyopathy (DCM), lysine acetyltransferase 2a (Kat2a) triggers ferroptosis by enhancing histone acetylation at the promoter regions of TfR1 and Hmox1, unveiling a previously unrecognized role of the Kat2a/Hmox1/TfR1 signaling axis [42]. Here, HMOX1 is linked to diabetic cardiomyopathy.