AKT1 and neoplasm: Since both the MEK/ERK and the PI3K/AKT signaling pathway play regulatory roles as downstream pathways of Ras, and abnormal activation of Ras/MEK/ERK pathway is also a common factor promoting tumor cell invasion and migration, we speculated that whether Ras/MEK/ERK pathway involved in the effect of quercetin on migration of LOVO cells.