Analysis of transcription factors in transcriptional regulatory relationships unraveled by sentence-based text mining (TRUUST) reveals that NFKB is the only regulator that simultaneously modulates EGFR, OPRM1, and GSK3B, indicating a central role in the interplay between inflammation, synaptic plasticity, and neuronal metabolism in MDD (Table 3). This evidence concerns the gene OPRM1 and major depressive disorder.