A similar, reduced 15‐year ASCVD risk associated with the presence of APOB variants was detected in each age tertile, sex, obesity category, presence or absence of T2D, lipid tertiles (LDL‐C, HDL‐C, total triglycerides), apolipoprotein AI (apoAI) tertiles, alcohol consumption and PNPLA3 rs738409 genotypes (see Figure S3). Here, APOB is linked to obesity due to melanocortin 4 receptor deficiency.