HINT1 and major depressive disorder: Patients with DNAJB2 variants also showed worse fatigue measured with FSS than HCs (42.0 [24.0–51.0] vs. 12.5 [12.0–16.0], p = 0.02) (Figure 2B), worse depression measured with BDI than patients with HINT1 variants (18.0 [13.0–35.0] vs. 6.5 [1.0–13.0], p = 0.008) and HCs (18.0 [13.0–35.0] vs. 1.5 [1.0–3.0], p = 0.002) (Figure 2C), and higher painDETECT scores than HCs (15.0 [7.0–30.0] vs. 0.0 [0.0–0.0], p = 0.009) (Figure 2D).