IL1B and obesity due to melanocortin 4 receptor deficiency: Obesity reduced caspase‐3 activation without altering caspase‐1 activation (Figure 3C,E), consistent with impaired apoptotic quality control rather than inflammasome‐driven pyroptotic cell death, which is characterized by membrane rupture, IL‐1β release, and chronic inflammation (Whelan et al. 2010).