Consistently, activation of protein kinases involved in DAMP signaling—c‐Jun N‐terminal kinase (JNK), nuclear factor‐κB (NFKB), and extracellular signal‐regulated kinase (ERK) (Kono and Rock 2008)—was elevated with the HF diet and entirely suppressed by DPR during obese conditions (Figure 3C,D). This evidence concerns the gene MAPK8 and hydrops fetalis.