Moreover, recent studies utilizing single‐cell RNA sequencing (scRNA‐seq) have revealed that Spp1 expression in MG is altered in various CNS disorders, including Alzheimer's disease (AD), major depressive disorder, and acute ischemic stroke (Scheepstra et al. 2023; Spitzer et al. 2022; Zhou et al. 2020). This evidence concerns the gene SPP1 and Alzheimer disease.