The difference in cerebral infarction size between groups of animals receiving HDAC6 inhibitors or control interventions was reported in five studies which collectively investigated seven different HDAC6 inhibitors or doses in total of 128 animals (Table 1, Figure 2).18,19,24,42,46 The timing of infarct size assessment relative to AIS induction varied between studies ranging from 24 h to 7 days post-AIS. This evidence concerns the gene HDAC6 and brain infarction.