HTT and Huntington disease: In this model, AAV-HTT (25Q) served as a control, and AAV-mHTT (103Q) was injected into the dorsal striatum to induce HD-like pathology.41 Robust mHTT aggregation was confirmed in the dorsal striatum of 103Q mice via immunohistochemistry (IHC) with an EM48 antibody (anti-mHTT antibody) (Supplementary Fig. 9b-c).