To investigate how WNT signaling contributes to HD pathologies, we performed RNA sequencing (RNA-seq) on the prefrontal cortex of 20 HD patients and 49 neuropathologically normal controls.21 Among the 19 WNT genes examined, WNT5B presented the highest basal expression and was markedly upregulated in HD patients (Fig. 1a, b and Supplementary Fig. 1a). This evidence concerns the gene WNT5B and Huntington disease.