In addition to MSN damage, the loss of parvalbumin-positive interneurons in the striatum is a recognized feature of HD pathology in both humans and rodents, contributing to dystonia and motor dysfunction.36,37 Parvalbumin-expressing interneurons in the striatum of N171-82Q + WNT5B mice presented significantly reduced Wisteria floribunda agglutinin (WFA) staining intensity, indicating the degradation of perineuronal nets (PNNs)–specialized ECM structures encapsulating these interneurons (Supplementary Fig. 10a). The gene discussed is WNT5B; the disease is Huntington disease.