MMP14 and Huntington disease: The estrogen and WNT signaling pathways are known to converge at the level of their effector transcription factors.28–30 To examine the effect of genistein under pathological conditions in HD, we first performed an MMP14 (-200 bp) promoter-luciferase assay in human astrocytes transduced with mHTT (103Q) (Fig. 4a).