Genistein suppressed NFATc2 nuclear translocation and inhibited MMP14 promoter activity in HD astrocytes (Fig. 4 and Supplementary Fig. 8), thereby attenuating the WNT5B–NFATc2–MMP14 signaling pathway, which was previously shown to be pathogenic in vivo. The gene discussed is NFATC2; the disease is Huntington disease.