The activation of WNT/Ca2+ signaling leads to the dephosphorylation and subsequent nuclear translocation of NFAT, which triggers the transcriptional activation of NFAT target genes.25 We analyzed the whole transcriptome and revealed that the genes whose expression was most significantly downregulated by WNT5B overexpression in HD mice were associated with TGFβ signaling and synapse pathways. This evidence concerns the gene WNT5B and Huntington disease.