To evaluate the effects of WNT5B overexpression on motor coordination and activity in HD mice, we performed rotarod, cylinder, and tail suspension tests two weeks after delivering AAV-GFAP(pro)-WNT5B-P2A-mCherry into the striatum of N171-82Q mice via bilateral stereotaxic injection (Fig. 6a). Here, GFAP is linked to Huntington disease.