NFATC2 and Huntington disease: While previous studies have implicated general WNT signaling abnormalities in neurodegenerative disease,42,43 our work specifically delineates the noncanonical WNT5B‒NFATc2 pathway as a bona fide mechanism underlying HD pathology and identifies it as a potential therapeutic target for HD and related neurodegenerative diseases.43 Both the knockdown of WNT ligands and the downstream transcription factor pangolin/TCF ameliorate survival in the Drosophila HD model.44 In this study, we discovered that WNT5B is upregulated in the striatal astrocytes of HD patients and HD model mice.