PVALB and Dystonia: In addition to MSN damage, the loss of parvalbumin-positive interneurons in the striatum is a recognized feature of HD pathology in both humans and rodents, contributing to dystonia and motor dysfunction.36,37 Parvalbumin-expressing interneurons in the striatum of N171-82Q + WNT5B mice presented significantly reduced Wisteria floribunda agglutinin (WFA) staining intensity, indicating the degradation of perineuronal nets (PNNs)–specialized ECM structures encapsulating these interneurons (Supplementary Fig. 10a).