To further clarify the mechanistic basis of SULF1‐driven stimulation of cancer cells, it would be informative to perform gain‐of‐function studies by knocking in SULF1 in HNCAFs, followed by analysis of growth factors and cytokine profiles in CAF‐conditioned media, as well as downstream signaling pathways in cancer cells exposed to SULF1‐expressing versus SULF1‐knockout CAFs. Here, SULF1 is linked to cancer.