In cluster 3 (HR-LowBeta), which is characterized by a relatively low insulin secretion and high polygenic risk score for beta cell failure, biological processes of cellular response to calcium and TGF-β signaling appear to be affected, both previously linked to kidney and atherosclerotic cardiovascular disease (ASCVD) [35, 36], which are future complications in this cluster. The gene discussed is TGFB1; the disease is atherosclerosis.