INS and posterior cortical atrophy: A separate two-arm RCT of 19 patients on AS or with biochemical recurrence of PCa following radical prostatectomy indicated that a 2-year home-based endurance training intervention slowed PSADT, lowered BMI, and improved adiponectin but did not alter insulin sensitivity or inflammatory markers, indicating that even longer interventions may or may not impact insulin sensitivity and inflammatory biomarkers [11].