KLK3 and neoplasm: There is evidence that exercise training can counteract the adverse side effects of androgen deprivation therapy (ADT) on body composition and metabolic markers in men with PCa.[12,13]Some studies have also shown that exercise can decrease prostate-specific antigen (PSA), a PCa tumor marker associated with PCa, and slow the rate of PSA increase, potentially indicating slower tumor progression [11, 14].