Here, we identified a heterozygous ClinVar LP/P SAMHD1 GV and a heterozygous IFIH1 GV with a CADD score > 30 in one patient each with an IDH-mutant glioma, providing further evidence for a link between AGS genes and glioma risk that we had previously described [6]. The gene discussed is IFIH1; the disease is glioma.