IDH2 and glioblastoma: In this study, two LoF variants (one of which was ClinVar LP/P) in SDHA possibly impacting succinate levels were detected in three patients with IDH-wildtype glioblastoma suggesting that the accumulation of succinate in glioblastomas with normal D-2-hydroxyglutarate levels may have similar oncogenic effects as the accumulation of D-2-hydroxyglutarate in IDH-mutant astrocytomas, and thus contribute to glioblastoma development.