H2AX and central nervous system cancer: Therefore, we determined the expression of markers of DNA double-strand breaks (DSB, phospho-H2AX), homology-directed repair of DSB (RAD51), and repair of DNA single-strand breaks (PARP1) as well as the expression of ATM and BRCA2 in available FFPE glioma sections from carriers of GVs in four genes conferring homologous recombination repair (HRR) deficiency, if mutated, i.e., ATM (n = 3 gliomas), BRCA2 (n = 3 gliomas), FANCA (n = 1 glioma), and SDHA (n = 2 gliomas) (Supplementary Fig. 8 online resource).