LRP1 and neoplasm: It was found that the levels of the α‐2 macroglobulin receptor (LRP/α2‐MR) were less expressed in the invasive sub‐clones of the A2058 melanoma cell line compared to the non‐invasive ones, supporting the hypothesis that the down‐regulation of the LRP/α2‐MR complex can increase tumour cell invasiveness [69].