[113] discovered that combining Asiatic acid (AA), a Smad7 agonist from Centella asiatica, with Naringenin (NG), a Smad3 inhibitor mainly from citrus fruits successfully rebalanced Smad3 and Smad7 signalling in TGF‐β‐rich tumour microenvironment. Here, SMAD7 is linked to neoplasm.