At the transcriptomic level, macrophages from women showed a strong upregulation of type I IFN (IFNα/β) signaling and proinflammatory cytokines, with increased expression of ISGs (e.g., IFIT2, IFIT3, IFIT5, OASL) as early as 6 h post‐infection. This evidence concerns the gene IFNA1 and infection.