As anticipated, the two specific CpG sites within the gene-body (cg10835584 and cg24771804) were highly methylated in PCa cell lines but not in RWPE1 non-tumorigenic prostate cells (Fig. 3B), and ONECUT2 gene-body DNA methylation was highly positively correlated with the protein levels (Fig. 3A). The gene discussed is ONECUT2; the disease is posterior cortical atrophy.