The mean score for each marker was also higher in samples from patients with periodontitis than in healthy controls (Fig. 2A): CD138 (2 ± 1 vs. 0 ± 0, p = 0.0001); CD3 (2 ± 2 vs. 0 ± 0, p = 0.0003); CD20 (2 ± 2 vs. 0 ± 0, p = 0.0042); CD68 (2 ± 2 vs. 1 ± 1, p = 0.0002); and CD66b (2 ± 2 vs. 0 ± 0, p = 0.0027). This evidence concerns the gene CD68 and periodontitis.