EIF2AK3 and Miyoshi myopathy: Indeed, in two independent datasets, patients with high CREB1 expression had greater levels of EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3, also known as PERK) and ATF6 (activating transcription factor 6) (Fig. 3B and Supplementary Fig S5A), two proteins involved in the survival of MM cells in the presence of misfolded proteins.