CHIP-sequencing analysis in MM cells (Supplementary Table S1) revealed that CREB1 directly binds to the promoters of NRF2 (Fig. 1K) and FBXO22 (Supplementary Fig. S3H), but not to those of BACH1 or TXNIP (Supplementary Fig. S3I, J). Here, FBXO22 is linked to Miyoshi myopathy.