These results are of potential clinical significance as numerous studies have shown that an increased M1/M2 ratio is associated with reduced tumor growth and better clinical outcomes across different tumor types.84–87 Given that an increased M1/M2 ratio is also associated with the recruitment/activation of CD8+ T cells,88 we evaluated the total number of CD8+ T cells in the pancreatic tumor samples upon antagomiR-182-5p treatment; however, we did not find any significant difference in CD8+ T cell numbers among different groups (Fig. 5n, o). The gene discussed is CD8A; the disease is pancreatic neoplasm.