CD8A and neoplasm: Further, using orthotopic, immunocompetent mouse models with varying immunogenic potential, we found that altering the payload of PaCa-derived exosomal miR-182-5p alleviates tumor burden in Pan02 and/or m3T-2D tumor-bearing mice, promotes CD8+ T cell activation, and restores M1/M2 ratio within the PaCa TME, thereby improving overall survival.