TGFB1 and permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome: We observed a significant increase in the levels of CD206, CD163, TGF-β, IL-10, and STAT3 mRNA in macrophages treated with PaCa patient-derived EVs as compared to the healthy donor EVs, as well as untreated macrophages (Fig. 4t), whereas CD80 (M1 marker) did not show any significant difference (Fig. 4t).