EDN1 and cancer: Noteworthy, we corroborated the finding of GSDME fine-tuning by the ETAR/ZEB1 axis in breast (MDA-MB-231) and colon (SW620) cancer cell lines, both expressing ETAR (Supplementary Fig. S2F), underscoring the ability of ET-1 to upregulate GSDME in the absence of macitentan (Fig. 2F, G) and in a ZEB1-dependent manner (Fig. 2M, N).