Similarly, the evidence of ZEB1/GSDME involvement in the regulation of EMT markers upon ETAR activation in breast and colon cancer (Fig. 4K, L and Supplementary Fig. S4E, F), suggested that this novel EMT-related nuclear function of GSDME may be common to various tumor histotypes, in addition to HG-SOC. This evidence concerns the gene EDNRA and malignant colon neoplasm.