Interestingly, ET-1-induced expression of GSDME was restrained by macitentan (Fig. 1J–L and Supplementary Fig. S1B, C), a non-selective ETAR/ETBR antagonist approved by regulatory agencies for the therapy of pulmonary arterial hypertension [10, 38–40]. This evidence concerns the gene GSDME and pulmonary arterial hypertension.