In line with the emerging contribution of ZEB1 in inflammatory responses driving cancer progression [44, 45], we observed a reduction in the ET-1-induced inflammatory cytokine pattern in cells silenced for ZEB1 or GSDME expression (Fig. 5A), suggesting an overlapping influence of GSDME and ZEB1 on ET-1-driven cytokine release. This evidence concerns the gene GSDME and cancer.