A microtubule-associated role for proteins that contain TPPP domains (also referred to as p25alpha domains) has been proposed in a number of physiological contexts in humans, including a role in myelination of oligodendrocytes (Fu et al, 2019), and linked to the neurodegenerative features of both Alzheimer’s and Parkinson’s diseases (Olah et al, 2011). Here, TPPP is linked to Parkinson disease.