IL6 and brain injury: Nevertheless, the observed concentration-dependent reduction in HEt fluorescence, together with CB3's suppression of proinflammatory cytokines (IL-6, IL-1β, TNF-α) and upregulation of IL-10, is consistent with CB3's previously reported capacity to modulate oxidative and inflammatory pathways in various pathological conditions, such as cardiovascular diseases, allergic airway disease, and traumatic brain injury [32,33,38,39,52,53].