And here by using DC-STAMP-overexpressing/knockdown AML cell models, we found DC-STAMP knockdown significantly reduced PI3K/AKT/mTOR pathway activation (decreased p-AKT and p-mTOR) and upregulated pro-apoptotic genes such as BAX and Caspase-3, while downregulating anti-apoptotic Bcl-2 [30]. This evidence concerns the gene CASP3 and acute myeloid leukemia.