The grouping of LATE-NC with hippocampal sclerosis was expected, as prior data suggest that there is likely a pathogenetic link between TDP-43 and hippocampal sclerosis.33,34 It is worth mentioning that even though individuals from each profile had disproportionately high burdens of specific copathologies (eg, LATE-NC with hippocampal sclerosis for profile 2), they also had fairly substantial burdens of other coexisting pathologies. This evidence concerns the gene TARDBP and nevus comedonicus syndrome.