TARDBP and proteostasis deficiencies: Prior literature on the neuropathologic correlates of cognitive decline and other functional changes are largely limited to either individual pathologies,25,26,27 specific patterns of copathologies (eg, ADNC and LATE-NC),28,29 or focusing on older adults with certain neuropathologic conditions (eg, TDP-43 proteinopathy).30 To our knowledge, the current study is among the few that have attempted to systematically disentangle complex patterns of copathology and to examine their associations with cognitive trajectories.