Neuropathologic assessments showed that 1107 participants (67.8%) met the pathologic criteria for AD, 448 (27.4%) had Lewy bodies, 226 (13.8%) had possible or definite hippocampal sclerosis, and about a third (594 participants [36.4%]) had TDP-43 cytoplasmic inclusions extending into hippocampus or entorhinal cortex and beyond. The gene discussed is TARDBP; the disease is Alzheimer disease.