Prior literature on the neuropathologic correlates of cognitive decline and other functional changes are largely limited to either individual pathologies,25,26,27 specific patterns of copathologies (eg, ADNC and LATE-NC),28,29 or focusing on older adults with certain neuropathologic conditions (eg, TDP-43 proteinopathy).30 To our knowledge, the current study is among the few that have attempted to systematically disentangle complex patterns of copathology and to examine their associations with cognitive trajectories. The gene discussed is TARDBP; the disease is Mental deterioration.