KEGG enrichment corroborated that the combined target set populates the key RA effector pathways Cytokine–Cytokine Receptor Interaction (hsa04060), TNF (hsa04668), IL-17 (hsa04657), JAK–STAT (hsa04630), NF-κB (hsa04064), Rheumatoid Arthritis (hsa05323) and Arachidonic Acid Metabolism (hsa00590) while GO emphasised inflammatory response, cytokine-mediated signaling, regulation of NF-κB, positive regulation of JAK–STAT, extracellular matrix degradation and nitric-oxide biosynthesis as dominant biological processes [28]. The gene discussed is TNF; the disease is rheumatoid arthritis.