STITCH mapping extended these insights by revealing that catechin and piceatannol strongly couple PTGS2 with antioxidant and immunoregulatory mediators (HMOX1, CSF2, DNMT1, PON1), while galangin connects CYP1B1 to MMP2, VCAM1 and MTOR, and umbelliferone links CYP2A6/UGTs to CCND1 and MPO, integrating drug metabolism, vascular inflammation, proliferative pannus formation and oxidative stress into the RA network. Here, PON1 is linked to rheumatoid arthritis.