However, the pleiotropic effects of IL-6 in the healing infarct and the induction of other IL-6 family members such as IL-11, oncostatin M and leukemia inhibitory factor that might compensate for the cytokine’s loss, may raise concerns regarding the potential role of IL-6 and its receptor as a therapeutic target in patients with MI remodeling [49]. The gene discussed is IL6; the disease is myocardial infarction.