,68 Notably, the mtDNA polymorphism m.1382A>C, found in East Asian men with type 2 diabetes, induces a K14Q substitution in MOTS-c, generating a partially bioinactive peptide, whereas the Parkinson disease-protective polymorphism m.2158T>C induces a K4R substitution in SHLP2, producing a more stable and protective peptide.68 The gene discussed is MT-RNR2; the disease is type 2 diabetes mellitus.