In a triple-transgenic mouse model of AD—harboring the Swedish mutation in amyloid precursor protein (APPswe), a P310L mutation in tau (tauP310L), and an M146V mutation in presenilin 1 (PS-1M146V), treatment with a synthetic Humanin analogue (S14G-HN) significantly reduced amyloid-beta plaque accumulation and improved cognitive performance.54 Here, MT-RNR2 is linked to Alzheimer disease.