On univariate analysis in the low ASMI group, several factors were associated with higher mortality: older age, male sex, higher NYHA class, lower LVEF, diabetes, CAD, atrial fibrillation, higher creatinine and NT‐proBNP levels, lower haemoglobin and LDL‐C levels, lower muscle strength, lower fat mass, lower exercise capacity and higher rates of loop diuretic and aspirin use (Table S2). This evidence concerns the gene NPPB and diabetes mellitus.