For example, the TP53 R175H mutation is one of the most common p53 mutations, present in 3%–5% of all cancers (particularly colorectal, breast, pancreatic, esophageal, ovarian, and non–small cell lung cancers) and nearly 7% of colorectal cancers (3, 9–11). The gene discussed is TP53; the disease is colorectal cancer.