NAT10 and neoplasm: To explore the role of Nat10 in modulating tumor immunity, we constructed stable Nat10-KO cell lines in murine CRC cells (MC38 and CT-26) using CRISPR/Cas9 (Figure 1A and Supplemental Figure 1F; supplemental material available online with this article; https://doi.org/10.1172/JCI196722DS1).