However, the inhibitory effect of Nat10 ablation on MC38 tumor growth was markedly greater in immunocompetent C57BL/6 mice than in immunodeficient BALB/c nude mice (Figure 1C and Supplemental Figure 1B), as reflected by reduced tumor volume and weight (Figure 1, D and E, and Supplemental Figure 1C). This evidence concerns the gene NAT10 and neoplasm.