To investigate the role of NAT10 in spontaneous colorectal carcinogenesis, we generated intestinal epithelium-specific Nat10 conditional KO (Nat10cKO) mice (Supplemental Figure 2, A and B) and established an azoxymethane/dextran sodium sulfate-induced (AOM/DSS-induced) CRC model (Figure 2A). This evidence concerns the gene NAT10 and colorectal carcinoma.