Thus, CRC cells were treated with actinomycin D (2.5 μg/mL) to examine RNA decay, and the stability of Dkk2 mRNA was markedly reduced in Nat10-KO cells, whereas the opposite effect was observed in cells overexpressing Nat10 (Figure 4N and Supplemental Figure 6D). Here, NAT10 is linked to colorectal carcinoma.