Moreover, in a mouse model of ICI-related cardiac injury, the involvement of activated myofibroblasts was uncovered, with myofibroblast-derived angiopoietin-like protein 2 (ANGPTL2) as a key mediator that promotes chemokine production and T cell recruitment, thereby exacerbating ICI-related autoimmune myocarditis (141). Here, ANGPTL2 is linked to autoimmune myocarditis.