FBXO11 and myelodysplastic syndrome: To evaluate the function of FBXO11 in human MDS cells, we used CRISPR/Cas9 or shRNA approaches to knock down FBXO11 in F-36P and MDS92 cells and assessed the effect on myeloid colony-forming ability of the cells in vitro (Figure 6, D and E, and Supplemental Figure 4A).