To better define the molecular mechanisms that link the contribution of radiotherapy and ARPIs to both systemic immunity and tumor immune microenvironment enrichment, we examined the effects of IR or ARPI alone or in combination in the Myc-CaP syngeneic murine prostate cancer model (Supplemental Figure 1, A–D; supplemental material available online with this article; https://doi.org/10.1172/JCI190928DS1). This evidence concerns the gene MYC and neoplasm.