Thus, restored expression of IKKε in hormone-responsive prostate cancer cells provides a plausible explanation, at least in part, for the previous observations that androgen deprivation therapy induces immunogenic changes in the tumor microenvironment of hormone-sensitive prostate cancers, including decreased tolerance and clonal expansion of effector T cells and stimulation of the antigen-specific adaptive immune response among others (41–44). This evidence concerns the gene IKBKE and prostate cancer.