CD8A and neoplasm: The reduction of intra-tumoral monocytes and neutrophils-to-CD8 T cell ratio is a favorable outcome for immunotherapy, as both of these immune cell types have been reported to act as immunosuppressors, inhibiting the cytotoxic activity of CD8+ T cells within the tumor microenvironment (Figure 7C; Sarkar et al., 2023; Gallina et al., 2006; Ouyang et al., 2024).