CD40LG and Cowden syndrome 1: Mean treponemal IgM levels rose with CS severity, peaking in the high-risk group (Possible or Confirmed Proven/Highly Probable CS: 29.9 ± 20.6 RLU) versus CS Less Likely (17.5 ± 20.8 RLU) and controls (3.5 ± 0.8 RLU; p<0.05).