Neonatal treponemal IgM antibodies were detected by the Chembio DPP Syphilis TnT Assay in all at-risk categories, with the highest mean levels observed in the high-risk CS group (Possible CS and Confirmed Proven or Highly Probable CS combined) (29.9 ± 20.6) compared to the CS Less Likely cohort (17.5 ± 20.8) or the negative controls (3.5 ± 0.8) (p < 0.05) (Table 2). The gene discussed is CD40LG; the disease is Cowden syndrome 1.