The objective of this pilot study was to assess the diagnostic value of IgM responses detected by the Chembio DPP Syphilis TnT research-use-only (RUO) point-of-care (POC) Assay in neonates categorized at birth into various CS risk scenarios, per the 2021 CDC STI Treatment Guidelines (7). The gene discussed is CD40LG; the disease is Cowden syndrome 1.