Biopsy-confirmed metastatic lesions in the bladder, rectum, and bone were observed with a pathologic diagnosis of prostate cancer with small cell features, which was supported by negative PSA, positive synaptophysin (SYP) and positive chromogranin (CHGA) on biopsy tissue immunohistochemistry (IHC) (Fig. 3D). The gene discussed is SYP; the disease is Familial prostate cancer.