Furthermore, increased transcript levels of the decoy receptor Il22ra2 (IL-22BP), which has been reported to be produced mainly by cDCs and CD4+ T cells41,42, could have attenuated IL-22 signaling and resulted in reduced Reg3g expression43 in HFD-fed male mice during the acute phase of infection, thereby predisposing them to more severe tissue damage. Here, IL22 is linked to infection.