Colocalization analyses with the melanoma risk signal suggests melanoma risk may share common causal variants with eQTLs for CASP8 (eCAVIAR CLPP = 0.012 for rs3769821) and FLACC1 (eCAVIAR CLPP = 0.05 for rs3769823) in mammary tissues, and FLACC1 in skin-not-sun-exposed (HyPrColoc PP = 0.97; SNP score = 0.62 and CLPP = 0.013 for rs3769823) and skin-sun-exposed tissues (HyPrColoc PP = 0.79; SNP score = 0.15 and CLPP = 0.012 for rs3769823) (Tables S19 and S20). This evidence concerns the gene CASP8 and melanoma.