Testing commonly occurring rs3769823/rs3769821/rs59308963 haplotypes in a reporter assay revealed cell-type dependent effects; the risk-associated A/C/ATTCTGTC haplotype was associated with lower expression relative to the protective G/T/- haplotype in melanocytes but higher expression in melanoma cells in the forward orientation relative to CASP8 transcription (Figure S17A, B). The gene discussed is CASP8; the disease is melanoma.