Of the remaining variants, rs3769821 was significant only in a joint analysis of data from both melanoma and HEK293T kidney cells (PMPRA v.1 = 3.11 × 10−4; Table S21) with direction of effect matching that observed in individual luciferase assays (reverse orientation) and consistent with the CASP8 eQTL. Here, CASP8 is linked to melanoma.