In this study, we focused on a melanoma susceptibility locus over the CASP8 gene on 2q33.1 that was originally identified by Barrett and colleagues5 and has since been replicated in a large melanoma GWAS meta-analysis (rs10931936-T, Pfixed = 2.12 × 10−12, Prandom = 2.17 × 10−8, OR = 1.08)10. This evidence concerns the gene CASP8 and melanoma.