Consistent with the weaker correlations between E4F1 and CASP8 in melanoma cells, E4F1 knockdown only modestly increased reporter activity for the A-risk allele, and only in the forward direction, suggesting a potentially weak repressor role for E4F1 in the context of melanoma cells (UACC903, Pforward = 8.05 × 10−4, Preverse = 0.74, Figure 5C; UACC1113, Pforward = 3.47 × 10−3, Preverse = 0.02, Figure S27C). This evidence concerns the gene CASP8 and melanoma.