While multiple genes within the TAD harboring the association signal had nominally significant eQTL, CASP8 is the only significant eQTL gene for the lead melanoma GWAS SNP (rs10931936; PCASP8 eQTL = 1.2 × 10−9, slope = 0.67, where lower CASP8 expression associated with the T-risk allele; Figure 2A, Table S10)36. Here, CASP8 is linked to melanoma.