CASP8 and melanoma: While no other genes had nominally significant melanocyte eQTLs for the sentinel melanoma risk SNP rs10931936, other strongly risk-associated SNPs at this locus were, notably for the CASP8-adjacent gene FLACC1 (rs3769821, P = 2.42 × 10−5, r2 to rs10931936 = 0.63; lead FLACC1 eQTL SNP rs796181752, P = 9.01 × 10−6; Table S10), where the direction of effect relative to risk allele is opposite to that for CASP8.