CASP8 and melanoma: For FLACC1, we note similar correlations in melanocytes to those observed for CASP8, with negative correlation observed for E4F1 (P = 3.40 × 10−6, r = −0.43), and positive correlations observed for REST and POU2F1 (REST, P = 1.72 × 10−10, r = 0.57; POU2F1, P = 4.71 × 10−12, r = 0.61), but do not observe consistent correlations for IRF2 or REST across melanoma datasets (Table S25).