We likewise tested each in individual luciferase reporter assays in two melanoma cell lines, again identifying rs3769823 as the only variant with consistently significant allelic cis-regulatory activities in both cell lines and in both forward and reverse orientations where the direction of reporter effect was consistent with the melanocyte FLACC1 eQTL but opposite that of CASP8 (e.g., the risk allele is associated with higher reporter expression). The gene discussed is CASP8; the disease is melanoma.