We were able to replicate this positive correlation specifically between IRF2 and CASP8 in independent panels of melanoma cell lines (P = 4.23 × 10−4, r = 0.38; Table S25) and the Leeds Melanoma Cohort (P = 8.74 × 10−4, r = 0.30; Table S25). The gene discussed is IRF2; the disease is melanoma.