Of the eight variants tested in either study, only rs3769823 showed an FDR-significant (FDR < 0.01) allelic effect in melanoma cells (PMPRA v.1 = 1.86 × 10−12, PMPRA v.2 = 1.09 × 10−52; Table S21), where the direction of effect was consistent with data from individual reporter assays and where the allelic effect is opposite to the CASP8 eQTL. This evidence concerns the gene CASP8 and melanoma.